Workshop: Managing Complex Drug-Drug-Gene Interactions in Real World Patients with PBPK

SafePolyMed invites researchers and clinicians to a hands-on workshop on 2 June 2026 exploring the quantitative management of complex drug–drug–gene interactions (DDGIs) using physiologically based pharmacokinetic (PBPK) modelling.

Real-world patients rarely fit textbook scenarios. Multimorbidity, comedication, and genetic variability create interaction patterns that are difficult to assess with conventional tools. Addressing these challenges is central to SafePolyMed’s ambition to improve drug safety through integrated modelling and decision support. In this workshop, participants will build and simulate DDGI scenarios based on literature-derived parameters, compare modelling strategies, and derive model-based dose recommendations for individual patients. The programme also demonstrates how these models are translated into clinical practice via a decision support system developed within SafePolyMed, providing a full workflow from model development to bedside application.

The workshop is designed for pharmacometricians, clinical pharmacologists, pharmacists, physicians, and researchers interested in precision dosing in complex patient populations. Participants should be familiar with PK-Sim® to benefit fully from the interactive sessions.

Date and venue: 2 June 2026, Valamar President Hotel, Dubrovnik - Croatia Cost: Free of charge

Seats are limited and demand is expected to be high. Register now to secure your place and gain hands-on experience in modelling real-world DDGI scenarios. For questions, contact Dr. Fatima Marok (fatima.marok[at]uni-saarland.de).